Article Analysis

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Thearticle “Risk of second primary lung cancer in women afterradiotherapy for breast cancer” explores the possibility ofcontracting lung cancer as a second type of cancer among women whoundergo radiotherapy for the breast cancer. The article was writtenby Trine Grantzau, Mette Skovhus Thomsen, Jens Overgaard, and MichaelVaeth and published online on June 5, 2014. The authors conducted acase control study to investigate the effect of radiotherapy dosevariation and the possibility of a primary lung cancer occurring as asecond cancer. The authors identified that the risk of contractingprimary lung cancer as a second cancer increase with about 8.5 % forevery Gray.

Thefindings of the research reported in the article have three majorbenefits to patients suffering from breast and primary lung cancer,other researchers, and other stakeholders in the health care sector.First, the research raises the awareness about a serious health risk(primary lung cancer) that occurs in the process of pursuing recoveryfrom the breast cancer through the radiotherapy. This awareness leadsto the second benefit, which is the creation of a basis for furtherinvestigation into the issue. The information and the findingsreported in the article about some of the possible factors (includingsmoking) that increase the risk of contracting lung cancer whenundergoing the radiotherapy for the breast cancer can be used forfurther research. Additional research will lead to the identificationof safer therapeutic protocols that will enhance the breast cancertreatment cancer without subject the patients to the risk ofcontracting lung cancer as a second cancer.

Thefindings reported in the article have economical, social, and ethicalimplications. First, the risk of contracting another type cancerduring the cancer therapy process means that the cost of health careservices for women suffering from the breast cancer will increase.Sickness has other social challenges (such as depression and stress)to patients, their relatives, and the society at large. This meansthat the lung cancer is an additional challenge to patients who havealready suffered from the breast cancer. In addition, the use of abreast cancer therapeutic protocol (radiotherapy) that has a seriousside effect (the lung cancer) on patients is a breach of researchethics. This means that the therapeutic procedure was applied tohuman beings before the elucidation of all potential side effects.

Thearticle relates to the course contents on malignancies and cancertherapy. The article focuses on the treatment of breast cancer amongwomen and the risk of contracting lung cancer as a side effect oftreating the breast cancer using the radiotherapy protocol. Theconclusion of the article emphasizes on research-based therapy, whichis the most appropriate way to go in order to ensure that theprotocols are effective and cause minimum damage, if any, on thebreast cancer patients.

Inconclusion, the findings reported in the article “Risk of secondprimary lung cancer in women after radiotherapy for breast cancer”indicates that the increases in the dose of the breast cancerradiotherapy are positively associated with the second primary lungcancer. The benefits of these findings include the increase in theawareness of the risk of using radiotherapy in the treatment ofbreast cancer, revoking researchers to carry out more research onbreast cancer therapy. The article has social, economic, and ethicalimplications.


Grantzau,T., Thomsen, M., Vaeth, M., Overgaard, J. “Risk of second primarylung cancer in women after radiotherapy for breast cancer”.Radiotherapyand Oncology111.3 (2014): 366-373.